Antimicrobial, Antioxidant and Cytotoxic Potential of Aerial Parts of Monotheca buxifolia

Authors

  • Sajjad Ahmad Department of Microbiology, Quaid-i-Azam University, Islamabad 45320
  • Maimoona Gull Center of Biotechnology and Microbiology, University of Peshawar, Old Jamrud Road, Qadir Abad, Peshawar, Khyber Pakhtunkhwa
  • Asma Shah Center of Biotechnology and Microbiology, University of Peshawar, Old Jamrud Road, Qadir Abad, Peshawar, Khyber Pakhtunkhwa
  • Faiz Ullah Khan Department of Pharmacy, Quaid-i-Azam University, Islamabad 45320
  • Muhammad Rafiq Department of Microbiology, Quaid-i-Azam University, Islamabad 45320
  • Ghusia Lutfullah Center of Biotechnology and Microbiology, University of Peshawar, Old Jamrud Road, Qadir Abad, Peshawar, Khyber Pakhtunkhwa
  • Alam Zeb Khan Department of Microbiology, Quaid-i-Azam University, Islamabad 45320
  • Farhat Amin Department of Bioinformatics, Shaheed Benazir Bhutto Women University, Charsadda Road, Larama Peshawar
  • Noreen Azhar Institute of Biotechnology and Genetic Engineering, The University of Agriculture, Professors Colony Road, Peshawar, Khyber Pakhtunkhwa
  • Muhammad Saleem Khan 6Department of Zoology, Government College University, Kotwali Road, Gurunanakpura, Faisalabad, Punjab 38000

DOI:

https://doi.org/10.5614/j.math.fund.sci.2019.51.2.4

Keywords:

antibacterial, antifungal, antioxidant, cytotoxic, Monotheca buxifolia

Abstract

In this study, different aerial parts of Monotheca Buxifolia were screened for their antibacterial, antifungal, and anti-oxidant activity. Extract of the fruit was most active against P. mirabilis, MSSA and M. morganii strains. Moreover, the methanolic fruit extract demonstrated good antibacterial properties against VRSA, S. aureus and Acinetobacter. Despite having good antibacterial properties, Monotheca buxifolia showed low antifungal activity. The cytotoxic activity was the highest in the pet-ether fruit extract, causing 60% of lethality against Artemia salina larvae with LD50 at 3.307. The highest scavenging activity was shown by the methanolic leaf extract in a concentration-dependent pattern. The findings of this study suggest that Monotheca Buxifolia has good antibacterial, antioxidant potential but low antifungal properties.

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2019-08-06

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