Artocarpin ad Heteroflavanone-A, Two Bioactive Flavonoids from Artocarpus champeden

Euis Holisotan Hakim, Emilia Evi Marlina, Didin Mujahidin, Sjamsul Arifin Achmad, Lukman Makmur, Emilio L. Ghisalberti

Abstract


Suatu senyawa flavon terisoprenilasi, yaitu 3-(y,y-dimetilalil)-6-(3-metil-1-butenil)-7-metoksi-5,2, 4-trihidroksiflavon atau artokarpin (1), bersama-sama dengan suatu senyawa flavanone langka, yakni 5-hidroksi-7,2,4,6-tetrametoksiflavanon atau heteroflavanon-A (2); telah ditemukan masing-masing pada kayu dan kulit batang tumbuhan Artocarpus champeden Spreng (Moraceae), suatu tumbuhan pangan yang endemik untuk Indonesia dan dikenal dengan nama cempedak. Struktur molekul kedua senyawa tersebut telah ditetapkan berdasarkan data fisika dan spektroskopi. Kedua senyawa flavonoid ini menghambat transportasi asam amino leusin melalui membran usus ulat sutera Bombyx mori, sedangkan artokarpin (1) juga menunjukkan toksisitas yang tinggi terhadap udang Artemia salina.

 

Artocarpin ad Heteroflavanone-A, Two Bioactive Flavonoids from Artocarpus champeden

An isoprenylated flavone, 3-(γ,γ-dimethylallyl)-6-(3-methyl-1-butenyl)-7-methoxy-5,2’,4’-trihydroxyflavone or artocarpin (1), together with rare flavanone derivative, 5-hydroxy-7,2’,4’,6’-tetramethoxyflavanone or heteroflavanone-A (2) were isolated from the wood and the tree bark of Arocarpus champeden Spreng (Moraceae), an endemic plant of Indonesia, locally known as cempedak. The structures of both compounds were elucidated based on physical and spectroscopic data. Both flavonoids inhibited the amino acid transport in Bombyx mori midgut, while artocarpin (1) also showed high toxicity against Artemia solina shrimp.


Keywords


Artemia salina; Artocarpus champeden Spreng; artokarpin; Bombyx mori; cempedak; flavon terisoprenilasi; heteroflavon A; menghambat transport asam amino; artocarpin; heteroflavanone A; inhibition of amino acid transport; isoprenylated flavone

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References


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