Paper ID:505

Propolis and Mangostin Inhibit Mammary Gland Cancer Development in Female Mice Balb/C

Marselina Irasonia Tan & Irham Hayati
School of Life Sciences and Technology,
Institut Teknologi Bandung, Jl. Ganesha 10, Bandung 40132, IndonesiaEmail: marsel@sith.itb.ac.id

Received June 19th, 2014, Revised September 28th, 2016, Accepted for publication December 20th, 2016

Abstract. Breast cancer development involves many processes, including angiogenesis and metastasis. Many factors play an important role in angiogenesis such as HIF-1α and in metastasis, i.e. FAK and Wnt2. The aim of this study was to observe the effect of propolis and mangostin on mammary gland cancer development and on the expression of wnt2 and FAK in Balb/C mice. Mammary gland tumor development in Balb/C mice was induced by DMBA. Mice were divided into 5 groups of treatment: negative control (K-); positive control (Dx) which were treated with doxorubicin (14.04 mg/kg b.w.); mice treated with Propolis (0.32 mg/kg bw) (P) or mangostin (0.128 mg/kg b.w.) (M) or combination of Propolis (0.32 mg/kg b.w.) and mangostin (0.128 mg/kg b.w.) (MP). Both Mangostin and propolis did not affect mice body weight. Treatment with propolis or treatment with propolis combined with mangostin was able to reduce tumor development activity in Balb/C mice. Moreover, combination of Mangostin and propolis is able to lower Wnt2, FAK and HIF-1α expression.  It can be concluded that combination of propolis and mangostin is potential to inhibit cancer development through downregulation of Wnt2, FAK, and HIF1α expression.

Keywords: angiogenesis; mammary cancer; mangostin; metastasis; propolis.

 

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