Paper ID:7168

Antimicrobial, Antioxidant and cytotoxic potential of aerial parts of Monotheca buxifolia

Sajjad Ahmad1, Muhammad Nadeem2, Maimoona Gull3, Faiz Ullah Khan4, Muhammad Rafiq1, Ghusia Lutfullah3, Asma Shah3, Hasnain Nangyal5, Zahid Khan6 &Muhammad Saleem Khan7

1Department of microbiology, Quaid-i-Azam University, Islamabad, Pakistan.
2Department of Biotechnology, Quaid-i-Azam University, Islamabad, Pakistan.
3Center of Biotechnology and Microbiology, University of Peshawar, Pakistan
4Department of Pharmacy, Quaid -i-Azam University, Islamabad, Pakistan.
5Department of Botany, Hazara University KPK, Pakistan.
6Faculty of Pharmacy, Federal Urdu University of Arts, Science and Technology Karachi, Pakistan.
7Department of Zoology, Government College University, Faisalabad, Pakistan*
*Corresponding Author: - Muhammad Saleem Khan

E-mail: samiikhan@yahoo.com

Received 14/02/18, Revision 13/12/18, Accept to Publish 14/12/18

Abstract. In this study, different aerial parts of Monotheca Buxifolia were screened for their antibacterial, antifungal, phytotoxic and anti-oxidant activity. Extract of fruits was most active against P. mirabilis, MSSA and M. morganii strains. Moreover, methanolic extract of fruits demonstrated good antibacterial properties against VRSA, S. aureus and Acinetobacter. Despite good antibacterial properties Monotheca buxifolia had low antifungal activity. The pet ether extract of fruit had good cytotoxic, which was most active causing 60% of lethality, with LD50 of 3.307 against Artemia salina larvae. Highest scavenging activity was shown by the methanolic leaves extract in concentration dependent pattern. Findings of this study suggested that Monotheca Buxifolia had good antibacterial, antioxidant potential but  low antifungal properties.

Keywords: antibacterial; antifungal; Antioxidant; cytotoxic; Monotheca, buxifolia

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