Acta Pharmaceutica Indonesia https://journals.itb.ac.id/index.php/acta <p><em><a href="http://journals.itb.ac.id/index.php/acta"><img class="imgdesc" src="http://journals.itb.ac.id/public/site/images/admin_acta/cover_issn.jpg" alt="" /></a></em></p> <p>Acta Pharmaceutica Indonesia merupakan jurnal resmi yang dipublikasikan oleh Sekolah Farmasi Institut Teknologi Bandung. Jurnal ini mencakup seluruh aspek ilmu farmasi sebagai berikut (namun tidak terbatas pada): farmasetika, kimia farmasi, biologi farmasi, bioteknologi farmasi, serta farmakologi dan farmasi klinik.</p> <p> </p> <p>Acta Pharmaceutica Indonesia is the official journal published by School of Pharmacy Institut Teknologi Bandung. The journal covers all aspects of pharmaceutical issues which includes these following topics (but not limited to): pharmaceutics, pharmaceutical chemistry, biological pharmacy, pharmaceutical biotechnology, pharmacology and clinical pharmacy.</p> <p> </p> <p>ISSN: 0216-616X</p> en-US actapharm_id@fa.itb.ac.id (Dr. Kusnandar Anggadireja) actapharm_id@fa.itb.ac.id (Acta Pharmaceutica Indonesia) Fri, 12 Feb 2021 07:18:21 +0700 OJS 3.2.1.0 http://blogs.law.harvard.edu/tech/rss 60 Pengembangan Metode Penentuan Kadar ZnO dalam Bedak Wajah Menggunakan Spektroskopi Serapan Atom https://journals.itb.ac.id/index.php/acta/article/view/6320 <p>Seng (Zn) dalam bentuk seng oksida (ZnO) merupakan bahan tabir surya yang terdapat dalam berbagai kosmetik antara lain dalam produk bedak. ZnO apabila berpenetrasi ke dalam kulit dalam jumlah berlebih dapat menyebabkan terjadinya fotosensitisasi sehingga penggunaannya di dalam kosmetik dibatasi oleh pemerintah. Tujuan dari penelitian ini adalah untuk mengembangkan metode penentuan kadar Zn dalam bedak dan menggunakannya untuk penentuan kadar Zn dalam beberapa sampel bedak yang beredar di Indonesia dengan menggunakan spektroskopi serapan atom (SSA). Persamaan linearitas metode dari hasil pengukuran larutan standar Zn yaitu y = 0,0088x + 0,0029 dengan koefisien regresi 0,9999. Metode analisis memiliki <em>Limit of Detection</em> (LOD) dan <em>Limit of Quantification </em>(LOQ) sebesar 0,101 µg/mL dan 0,306 µg/mL. Pengukuran kadar ZnO pada 12 sampel bedak yang beredar di pasaran menunjukkan hasil yang beragam dengan rentang 1,74 – 25,76 %, dari hasil tersebut diketahui bahwa 2 dari 12 sampel mengandung ZnO dengan kadar yang melebihi persyaratan Badan Pengawas Obat dan Makanan (BPOM) Republik Indonesia.</p> Sophi Damayanti, Eko Prayitno, Farel Fahrizal, Adi Suwandi Copyright (c) https://journals.itb.ac.id/index.php/acta/article/view/6320 Fri, 31 Aug 2018 00:00:00 +0700 ISOLASI SENYAWA MARKER DARI EKSTRAK AIR DAUN KELOR (MORINGAN OLEIFERA LAMK.) https://journals.itb.ac.id/index.php/acta/article/view/6816 <p>Kelor (<em>Moringaoleifera</em>Lamk.) adalah tanaman termasuk dalam famili Moringaceae yang telah lama digunakan dalam pengobatan beberapa penyakit secara tradisional. Penggunaan secara empiris tersebut telah dibuktikan secara ilmiah. Penelitian ini bertujuan untuk mengisolasi senyawa marker dari ekstrak air daun kelor. Penelitian ini dimulai dari pembuatan ekstrak, karakterisasi simplisia, dan penapisan fitokimia. Pembuatan ekstrak dilakukan dengan cara daun diblender dengan penambahan aquades kemudian disaring. Filtrat yang diperoleh dikumpulkan, kemudian dikeringkan menggunakanalat <em>freeze dryer</em><em> </em>sampai diperoleh ekstrak kering.Ekstrak air daun kelor difraksi nasi dengan metode ekstraksi cair-cair menggunakan pelarut etil asetat. Fraksi etil asetat disubfraksinasi dengan menggunakan kromatografi kolom klasik. Pemurnian dilakukan dengan menggunakan kromatografi lapis tipis preparatif dan uji kemurnian dilakukan dengan menggunakan KLT pengembangan tunggal dan KLT dua dimensi. Isolat dikarakterisasi menggunakan KLT dengan penampak bercak spesifik dan pereaksi geser. Dari hasil pemurnian didapatkan senyawa murni dengan bentuk amorf. Berdasarkan data spektroskopi UV diduga isolat yang diperoleh merupakan flavonol, dimana terdapat OH pada posisi C3, C7, dan C4’, serta tidak adanya orto di-OH pada cincin B.</p> Elfahmi Elfahmi, Maria Immaculata Iwo, Sartika Yuniarti Copyright (c) https://journals.itb.ac.id/index.php/acta/article/view/6816 Fri, 31 Aug 2018 00:00:00 +0700 The Off-Label Use of Oxcarbazepine In Indonesia https://journals.itb.ac.id/index.php/acta/article/view/6760 <p>Oxcarbazepine is a second-generation anticonvulsant drug that is a keto analog of carbamazepine. Oxcarbazepine was approved by The National Agency of Drug and Food Control Indonesia (NA-DFC) for generalized epilepsy, tonic-clonic primary and partial epilepsy with or without secondary generalization. However, as other anticonvulsants, oxcarbazepine is also often used without approved indication (off-label). The aim of this study is to investigate the off-label use of oxcarbazepine through an observational study with retrospective data collection. Data were obtained from four hospitals in Yogyakarta, namely Dr. Sardjito Hospital, UGM Hospital, PKU Muhammadiyah Hospital and Bethesda Hospital. Off-label use of oxcarbazepine was identified based on official registration by NA-DFC Indonesia. The results of this study showed that the use of oxcarbazepine in 2014 was 224 prescriptions, which 117 (52.68%) was off-label. Most off-label indications according to ICD-10 were cephalgia 48 (41.03%), followed by trigeminal neuralgia 35 (29.91%), stroke 6 (5.13%) and others 29 (23.93%). From these study, the off-label use of oxcarbazepine was mostly in the cases of neuropathic pain.</p> Bangunawati Rahajeng, Zullies Ikawati, Tri Murti Andayani, Iwan Dwiprahasto Copyright (c) https://journals.itb.ac.id/index.php/acta/article/view/6760 Fri, 31 Aug 2018 00:00:00 +0700 Analysis of Health-related Quality of Life Determinants in Adult Ashmatic Patients in a District Hospital in East Jakarta https://journals.itb.ac.id/index.php/acta/article/view/6761 <p><strong>Background: </strong>Uncontrolled asthma leads to patients’ poor outcomes and decreases health-related quality of life/HRQoL. Little research has been done to analyze the determinants of HRQoL in asthmatics patients. <strong>Objective: </strong>To determine asthma control and patients’ compliance levels, and evaluate the appropriateness of medicine use and determinants of HRQoL. <strong>Methods: </strong>During this prospective study, adult asthmatic patients who currently experienced asthma attack were evaluated in asthma clinic of a district hospital in Jakarta and administered study questionnaires. Demographic variables and data related to asthma control, patients’ compliance level and the appropriate use of medications were summarized using descriptive statistics. The determinants of HRQoL were determined using bivariate and multivariate regression analysis. All data were analyzed using SPSS version 22.0. <strong>Results: </strong>There were 11 males and 43 females aged approximately 45 years old. More than 50% of the patients had uncontrolled asthma and low level compliance to their medications. Nearly all medicines used were inappropriate according to National Asthma Treatment Guideline. Bivariate correlation test revealed four factors which significantly determined the total score of HRQoL, namely asthma duration (P=0.033), asthma control level (p=0.007), asthma severity level (p=0.001) and the presence of smoke exposure in neighbourhood (p=0.032). Further, multivariate analysis showed only the presence of smoke exposure significantly affecting patients’ quality of life. <strong>Conclusion: </strong>This study uncovered the majority of patients had uncontrolled asthma status and low level of compliance to their medications. In addition, this study highlighted the exposure of smoke exposure as the solely determinant of HRQoL amongst asthmatic patients.</p> Hesty Utami Ramadaniati, Sesilia Andriani Keban, Christine Meidiawati Copyright (c) https://journals.itb.ac.id/index.php/acta/article/view/6761 Fri, 31 Aug 2018 00:00:00 +0700 Determination of sun protective factors (SPF) and antioxidant activity of ethanolic extract of rambutan rind (Nephelium lappaceum L.) https://journals.itb.ac.id/index.php/acta/article/view/6767 <p><strong>Background</strong>, The fruit peels of rambutan (<em>Nephelium lappaceum</em> L)are organic garbage with many potential health benefits but have not been used optimally. <strong>Purposes</strong> This study aims to determine the sun protective factor (SPF) and antioxidant activity of ethanolic extract of rambutan rind. <strong>Methods</strong> The rambutan (<em>Nephelium lappaceum</em> L) rind was extracted by maceration method using ethanol as solvent. A simple, rapid and reliable in vitro method was used to assess the SPF values by measuring the absorbance of diluted extract between 290-320 nm at every 5 nm intervals using Ultraviolet Spectrophotometry. The SPF values were calculated based on the recorded absorbance using a simple mathematic equation developed by Mansur. The antioxidant activity of rambutan rind was determined by the 1,1-diphenyl-2-picryl-hydrazil (DPPH) assay whereas vitamin C as positive control.  <strong>Results</strong> The SPF values of rambutan rind in concentration series of 50, 100, 150 and 200 ppm were 6,47±0,45 , 9,26±0,28, 13,01±0,33, and 16,17±0,63 respectively. The IC<sub>50</sub> value of rambutan rind was 41,47 ± 3,89 µg/ml whereas the IC<sub>50</sub> value of vitamin C was 24,87 ± 0,69 µg/ml. <strong>Conclusion</strong> Based on the result, the ethanolic extract of rambutan rind has potential as sunscreen and antioxidant.</p><p> </p> Ida Adhayanti, Nurisyah Nurisyah, Alfrida Monica Salasa, Arisanty Arisanty, Santi Sinala Copyright (c) https://journals.itb.ac.id/index.php/acta/article/view/6767 Fri, 31 Aug 2018 00:00:00 +0700 Front Matter Vol 43 No 1 (2018) https://journals.itb.ac.id/index.php/acta/article/view/15735 Acta Pharmaceutica Indonesia Copyright (c) https://journals.itb.ac.id/index.php/acta/article/view/15735 Fri, 31 Aug 2018 00:00:00 +0700