Communication in Biomathematical Sciences <p><a href=""><img class="imgdesc" src="" alt="" width="189" height="265" /></a></p> <p style="text-align: justify;"><strong>Communication in Biomathematical Sciences</strong> welcomes full research articles in the area of <em>Applications of Mathematics in biological processes and phenomena</em>. Review papers with insightful, integrative and up-to-date progress of major topics are also welcome. Authors are invited to submit articles that have not been published previously and are not under consideration elsewhere.</p> <p style="text-align: justify;">Review articles describing recent significant developments and trends in the fields of biomathematics are also welcome.</p> <p style="text-align: justify;">The editorial board of CBMS is strongly committed to promoting recent progress and interdisciplinary research in Biomatematical Sciences.</p> <p style="text-align: justify;"><strong>Communication in Biomathematical Sciences published by <a href="" target="_blank" rel="noopener">The Indonesian Biomathematical Society</a>.</strong></p> <p>e-ISSN: <a href="" target="_blank" rel="noopener">2549-2896</a></p> <p>Accreditation <a href="" target="_blank" rel="noopener">No. 85/M/KPT/2020</a></p> The Indonesian Bio-Mathematical Society en-US Communication in Biomathematical Sciences 2549-2896 Association of Overexpression of PLD6, CHRAC1 and PDCD5 with Type 2 Diabetes Mellitus <p><strong><em>Background:</em></strong> Diabetes type 2 is a metabolic disease characterized by high blood sugar caused by insulin resistance and/or insufficient insulin production. The pathogenesis of DT2 is complicated by both genetic predisposition and environmental and lifestyle variables. At least 150 genetic variants have been linked to the probability of having DT2 in studies. <strong><em>Aim</em></strong>: The purpose of this study was to determine the expression of <em>PLD6</em>, <em>CHRAC1, and PDCD5 </em>in type 2 diabetic patients. <strong><em>Materials and Methods</em></strong>: Information on 12 DT2 patients was obtained from the GEO using the ID (GSE34008). The analysis tools GEO2R, STRING, UALCAN, and TCGA were used to accomplish the study's goal. The human protein atlas provided details on gene cancer. <strong><em>Results:</em></strong> Only ten genes with expression differences ranging from low to high were selected. <em>PLD6</em>, <em>CHRAC1, and PDCD5 </em>were detected to have higher expression in patients compared to controls. The number of patients with primary pancreatic adenocarcinoma for <em>SLC16A4</em>, <em>DERK2</em>, and <em>CHRAC1</em> was greater than that of healthy controls. Concerning the severity of cancer, all chosen genes demonstrated a greater proportion of affected individuals compared to the control group of healthy individuals. <strong><em>Conclusions</em></strong>: <em>PLD6</em>, <em>CHRAC1</em>, and <em>PDCD5</em> were considerably more common in grade 4 pancreatic adenocarcinoma patients. Patients with stage 4 pancreatic cancer are most likely to show elevated expression of these genes.</p> Ali Dawood Zayd Omer Alyaa Al-Omari Copyright (c) 6 2 THE DYNAMICS OF CASSAVA MOSAIC DISEASE VIA CAPUTO FRACTIONAL DERIVATIVE <p>In this paper, we investigate a new fractional model of Cassava Mosaic Disease (CMD) using the Caputo derivative. For this purpose, we provide some observational results by examining the model to establish the existence of a unique solution, as well as by proving the solution's positivity and boundedness. The basic reproduction number R0 is calculated using the next-generation matrix, and the local stability of the equilibrium points is obtained based on the Routh-Hurwitz criterion. Special attention is given to sensitivity analysis to identify the parameter that affects the transmissibility of CMD. Furthermore, by employing the predictor-corrector approach, the numerical results from the system with the Caputo derivative will produced. As a consequence, the graphical presentations have visualized the potency of fractional order derivatives in the transmission of CMD.</p> nezha KAMALI Copyright (c) 6 2 Numerical Bifurcations and Sensitivity Analysis of an SIVPC Cervical Cancer Model <p>We consider a mathematical model of cervical cancer based on the Natural History of Cervical Cancer. The model is a five dimensional system of the first order of ordinary differential equations that represents the interaction between the free Human Papilloma Virus (HPV) population and four cells sub-populations, i.e., the normal cells, infected cells by HPV, precancerous cells, and cancer cells. We focus our analysis to determine the existence conditions of the nontrivial equilibrium point, the bifurcations, and the sensitivity of the parameters that play important roles in metastasis. Based on the basic reproduction ratio of the system, we found that the infection rate, the new viruses production rate, the free viruses death rate, the infected cells growth rate, and the precancerous cells progression rate play important roles for the cancer spreads in the cellular level. By applying sensitivity and numerical bifurcation analysis, we found that there are some important bifurcations that trigger some irregular behaviours of the system, i.e., fold, Hopf, cusp and Bogdanov-Takens.</p> Tri Sri Noor Asih Copyright (c) 6 2 A Fractional Order Derivatives for the Transmission Dynamics of Coffee Berry Diseases (CBD) <p><span class="fontstyle0">This study examined the dynamics of a fractional-order Atangana Baleanu Caputo (ABC) model for coffee berry disease. The vector and coffee berry populations were both considered in the model. The basic reproduction number and endemic and disease-free coffee berry equilibria were investigated. Using the value of the basic reproduction number, the asymptotic stability of these equilibria is further investigated, both locally and globally. The numerical method suggested by Toufic and Atangana is used to roughly derive the solution to the problem. The disease tends to slow down as the fractional order (</span><span class="fontstyle2">σ</span><span class="fontstyle0">) declines, based on the numerical simulation for different fractional orders.</span> </p> Abayneh Kebede Fantaye Copyright (c) 6 2