Journal of Mathematical and Fundamental Sciences 2023-05-07T11:35:44+07:00 Prof. Dr. A. Agung Nugroho Open Journal Systems <p><img class="imgdesc" src="" alt="" width="173" height="220" /></p> <p style="text-align: justify;"><em>Journal of Mathematical and Fundamental Sciences </em>welcomes full research articles in the area of Mathematics and Natural Sciences from the following subject areas: Astronomy, Chemistry, Earth Sciences (Geodesy, Geology, Geophysics, Oceanography, Meteorology), Life Sciences (Agriculture, Biochemistry, Biology, Health, Medical, Pharmacy), Mathematics, Physics, and Statistics. New submissions of mathematics articles starting in January 2020 are required to focus on applied mathematics with real relevance to the field of natural sciences.</p> <p style="text-align: justify;">Starting from Vol. 1, No. 1, 1961, full articles published are available online at ITB Journals and indexed by <a href=";origin=recordpage">Scopus</a>, <a href=";ISSN=2337-5760">Web of Science (Emerging Sources Citation Index) - Clarivate Analytics</a>, <a href=";tip=sid&amp;clean=0">Scimago JR</a>, <a href="">Directory of Open Access Journals (DOAJ)</a>, <a href=";user=xdqQsgUAAAAJ&amp;view_op=list_works&amp;sortby=pubdate">Google Scholar</a>, <a href=",p24780956,3.html">Index Copernicus</a>, <a href=";colors=7&amp;lang=en&amp;jq_type1=QS&amp;jq_term1=journal+of+mathematical+and+fundamental+sciences">The Elektronische Zeitschriftenbibliothek (EZB) by University Library of Regensburg</a>, <a href=";Find=Journal+of+Mathematical+fundamental+Sciences&amp;GetResourcesBy=QuickSearch&amp;resourceTypeName=allTitles&amp;resourceType=&amp;radioButtonChanged=">EBSCO Open Science Directory</a>, <a href="">ASEAN Citation Index</a>, <a href="">Garba Rujukan Digital (Garuda)</a> and <a href="">Science and Technology Index (SINTA)</a>.</p> <p style="text-align: justify;">The journal has been also accredited for five years based on The Decree of Directorate General of Research and Development Strengthening, Ministry of Research, Technology and Higher Education of the Republic of Indonesia <a href="">No. 030/E/KPT/2018</a>, dated on October 24th, 2018.</p> <p style="text-align: justify;">Published by Institute for Research and Community Services, Institut Teknologi Bandung, in collaboration with <a href="">Indonesian Chemical Society (Himpunan Kimia Indonesia - HKI)</a>.</p> <p>ISSN: 2337-5760; E-ISSN: 2338-5510</p> <p><strong><u>Publication History</u></strong></p> <p><strong>Formerly known as:</strong></p> <ul> <li>ITB Journal of Science (2008 - 2012)</li> <li>Proceedings ITB Science and Technology (2003 - 2007)</li> <li>Proceedings ITB (1961 - 2002)</li> </ul> <p>Back issues also can be read online at</p> <p><a title="SCImago Journal &amp; Country Rank" href=";tip=sid&amp;exact=no"><img src=";title=true" alt="SCImago Journal &amp; Country Rank" border="0" /></a></p> Synthesis of Human Antibodies Against HBsAg in Newly Established Chinese Hamster Lung (CHL-YN) Cell Line 2023-03-10T10:58:34+07:00 Meutia Diva Hakim Noriko Yamano- Adachi Takeshi Omasa Marselina Irasonia Tan Lia Dewi Juliawaty Ernawati Arifin Giri-Rachman <p>Hepatitis B immunoglobulin (HBIG) is an effective treatment for hepatitis B, including postexposure prophylaxis of HBV infection, prevention of HBV reinfection in liver transplant patients, and reducing sexual transmission. This study investigated the synthesis of human IgG antibodies that specifically target HBsAg subtype <em>adr</em> in CHL-YN cells, a newly established cell line that grows faster than CHO-K1. To achieve the synthesis of human IgG antibodies, a plasmid vector encoding DNA sequences for human IgG antibodies against HBsAg was constructed and then transiently transfected into CHL-YN cells. The expression and antigen-binding capacity of the recombinant human IgG antibodies were analyzed using western blot and ELISA. The results showed successful expression and secretion of human IgG antibodies that recognize HBsAg subtype <em>adr</em> in CHL-YN cells. The ELISA test confirmed the specificity of the human IgG antibodies towards HBsAg subtype <em>adr</em>. Thus, this study concluded that human IgG antibodies that target HBsAg subtype <em>adr</em> were transiently expressed in CHL-YN cells.</p> 2023-05-07T00:00:00+07:00 Copyright (c) 2023 Journal of Mathematical and Fundamental Sciences Havanensin-type Limonoids from the Stem Bark of Chisocheton pentandrus (Meliaceae) 2022-12-29T12:19:07+07:00 Dudi Runadi Purnama Purnama Supriatno Salam Nulelasari Nurlelasari Desi Harneti Tri Mayanti Rani Maharani Unang Supratman Yoshihito Shiono <p>A new limonoid, belonging to the havanensin-type, called pentandricine E (<strong>1</strong>), alongside four other known types, i.e., trichilenone acetate (<strong>2</strong>), toonaciliatones C (<strong>3</strong>), 11α-acetoxyazadirone (<strong>4</strong>) and ceramicine I (<strong>5</strong>), were found in <em>Chisocheton pentandrus</em> stem bark. The structures of the isolated <strong>1</strong>-<strong>5</strong> were identified by NMR spectroscopy and HRTOFMS. Pentandricine E (<strong>1</strong>) displayed the highest cytotoxicity toward the MCF-7 breast cancer line with an IC<sub>50</sub> value of 63.27 ± 0.21 mM.</p> 2023-05-15T00:00:00+07:00 Copyright (c) 2023 Journal of Mathematical and Fundamental Sciences Applying Fluorescence Dissolved Organic Matter Spectra and Phytoplankton Biology Index for Assessing Urban River Quality 2023-02-10T22:01:18+07:00 Okik Hendriyanto Cahyonugroho Sucipto Hariyanto Ganden Supriyanto <p>The relationship between phytoplankton dynamics and dissolved organic matter (DOM) in aquatic systems based on fluorophore organic matter properties results in poor implementation of methods for water quality monitoring. This study aimed to investigate the relation between fluorophore organic matter and phytoplankton index and to estimate the phytoplankton index by fluorescent organic components for water quality assessment. The research was conducted by sampling urban river water, followed by measuring the biological phytoplankton index and dissolved organic matter during the wet and dry seasons. Fluorescence Excitation Emission Matrices (FEEMs) analysis combined with Parallel Factor (PARAFAC) analysis identified three main components of the fluorescence organic matter, i.e., a fulvic acid-like component (C1) and humic acid-like components (C2 and C3), in the aquatic system, whether in the dry season or the wet season. C1 was mainly generated by phytoplankton species, i.e., <em>Nitzschia</em> sp., <em>Plectonema</em> sp., <em>Navicula</em> sp., and <em>Pinnularia</em> sp., and C2 and C3 had a less significant relationship with phytoplankton species. The diversity of Bacillariophyta had a stronger contribution to the release of DOM than the diversity of Cyanobacteria. The abundance index of a particular phytoplankton species can be used to determine the organic components of FEEM-derived fluorescence organic matter.</p> 2023-05-15T00:00:00+07:00 Copyright (c) 2023 Journal of Mathematical and Fundamental Sciences