MODIFICATION NATURAL ZEOLIT BY PLANTING INHIBITOR OF Cu WITH BATCH METHOD AS RAW MATERIAL FOR ANTISEPTIC MEDICINE

Dewi Fatimah

Abstract


Natural zeolite can be develop as alternative raw materials
pharmaceutical product, particularly as an absorbent of microbial pathogens and it is widely spread in
almost province at Indonesia. The study conducted by modifying natural zeolite by planting inhibitor of Cu
which functions as raw materials for medicine, especially as an antiseptic carrier. Process of planting Cu
was conducted on Zeolite-H with variation stirring time of 2,4 6, and 8 hours at room temperature. Inhibitor
planting process by batch methods was conducted on batch reactor. The result showed that purification
process could be reduce a free oxides from Si, Al, Ti, Ca, and Fe which covered crystal structure and there
is not occurred a peaks degradation of modernite and clinoptilolite on XRD diffractogram. Through SEM
analysis can be seen form of modernite and clinoptilolite crystal that result of purification process more
clearer. The EDX analysis showed that conversion to zeolite-Cu was successfully done and highest
absorption of ASS at stirring time of 6 hours with concentration Cu of 299,5 ppm. Dynamic oligo antiseptic
carrier test from zeolite-Cu was conducted on Candida albicans and Escherichia coli Growth. The media
used were gel nutrient on various concentrations at incubation time of 30oC for 24-48 hours. The result
showed that Zeolite-Cu can significantly reduce a Candida albicans and Escherichia coli growth.

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