Havanensin-type Limonoids from the Stem Bark of Chisocheton pentandrus (Meliaceae)
DOI:
https://doi.org/10.5614/j.math.fund.sci.2023.54.3.2Keywords:
Chisocheton pentandrus, havanensin-type, MCF-7, pentandricine EAbstract
A new limonoid, belonging to the havanensin-type, called pentandricine E (1), alongside four other known types, i.e., trichilenone acetate (2), toonaciliatones C (3), 11?-acetoxyazadirone (4) and ceramicine I (5), were found in Chisocheton pentandrus stem bark. The structures of the isolated 1-5 were identified by NMR spectroscopy and HRTOFMS. Pentandricine E (1) displayed the highest cytotoxicity toward the MCF-7 breast cancer line with an IC50 value of 63.27 0.21 mM.
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