A Pyrone and Flavonoid Derivatives from  Cryptocarya crassinervia and their Inhibitory Properties against Receptor Tyrosine Kinases

Dian  Nugraheni; Elvira  Hermawati; Hendra Helmanto; Dikhi Firmansyah; Yana Maolana Syah; Lia Dewi Juliawaty

doi:10.5614/j.math.fund.sci.2024.55.3.5

Authors

Dian Nugraheni Organic Chemistry Division, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Jalan Ganesha 10, Bandung 40132, Indonesia
Elvira Hermawati Organic Chemistry Division, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Jalan Ganesha 10, Bandung 40132, Indonesia
Hendra Helmanto Research Center for Plants Conservation Botanic Garden and Forestry, National Research and Innovation Agency, Gedung Kusnoto, Jalan Ir. H. Juanda No. 18, Bogor 16122, Indonesia
Dikhi Firmansyah Organic Chemistry Division, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Jalan Ganesha 10, Bandung 40132, Indonesia
Yana Maolana Syah Organic Chemistry Division, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Jalan Ganesha 10, Bandung 40132, Indonesia
Lia Dewi Juliawaty Organic Chemistry Division, Faculty of Mathematics and Natural Sciences, Institut Teknologi Bandung, Jalan Ganesha 10, Bandung 40132, Indonesia

DOI:

https://doi.org/10.5614/j.math.fund.sci.2024.55.3.5

Keywords:

?-pyrone, Cryptocarya crassinervia, flavone glycosides, Lauraceae, receptor tyrosine kinases

Abstract

A new a-pyrone, i.e., cryptocrassinervione (1), and a new flavone glycoside, i.e., kaempferol-3-O-rhamnosyl-2-O-apiofuranoside (4), were isolated from EtOAc extract of Cryptocarya crassinervia leaves. Along with these compounds, two known flavone glycosides, namely afzelin (2) and quercitrin (3), were also isolated. The structures of the new compounds were determined based on NMR and mass spectral data. Compounds 1?4 were examined against eight receptor tyrosine kinases (RTKs) (EGFR, HER2, HER4, IGF1R, InsR, KDR, PDGFR?, and PDGFR?), which showed that these compounds were moderately active against EGFR, with inhibition percentages of 55, 49, 41, and 44%, respectively. They were weakly active against HER2, with inhibitions of 17, 20, 18, and 16%, respectively. However, they were not active against the rest of the RTKs. Nevertheless, compounds 1?4 have potency as inhibitors of EGFR.

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