Penta- and Tetra-cyclic Triterpenoids from Aglaia cucullata Stembark and Cytotoxicity against Cancer and Normal Cells

Kindi  Farabi; Wahyu  Safriansyah; Desi Harneti; Hadi Kuncoro; Sofa Fajriah; Unang Supratman

doi:10.5614/j.math.fund.sci.2025.57.2.1

Authors

Kindi Farabi Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, 45363, Indonesia
Wahyu Safriansyah Eijkman Research Center for Molecular Biology, National Research and Innovation Agency, Jalan Raya Bogor Km. 46, Cibinong, Bogor, 16911, Indonesia
Desi Harneti Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, 45363, Indonesia
Hadi Kuncoro Faculty of Pharmacy, Universitas Mulawarman, Samarinda, 75123, East Kalimantan, Indonesia
Sofa Fajriah Research Center for Pharmaceutical Ingredients and Traditional Medicine, National Research and Innovation Agency (BRIN), Cibinong Science Center Complex ? BRIN, Cibinong 16911, Bogor, West Java, Indonesia
Unang Supratman Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, 45363, Indonesia

DOI:

https://doi.org/10.5614/j.math.fund.sci.2025.57.2.1

Keywords:

Aglaia, Aglaia cucullata, cytotoxic activity, Meliaceae, penta- and tetracyclic triterpenoids

Abstract

Three triterpenoid compounds, belonging to the penta- and tetracyclic groups, were successively isolated from the stembark of Aglaia cucullata and identified as b-amyron (1), dammaradienon (2), and cabralealactone (3). After extensive extraction, chromatographic separation and purification, compounds 1 to 3 were gained. Spectroscopic analysis in addition to HRMS, FTIR, 1D and 2D NMR analysis were utilized to determine the chemical structure. After that, compounds 1 to 3 were tested against breast cancer, melanoma as well as normal kidney cells (MCF-7, B16-F10, and CV-1, respectively). The resulted cytotoxicity test revealed that compound 1 had the best cytotoxicity against all cells compared with the other isolated compounds. This result suggests that the pentacyclic triterpenoid core in compound 1 increases cytotoxicity compared with a tetracyclic skeleton.

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