Pengaruh Pemberian Minyak Biji Kelor (Moringa seeds oil) Terhadap Kadar Trigliserida Pada Darah Tikus Putih Jantan Galur Wistar (Rattus norvegicus)
Keywords:
Moringa seed oils; Triglyceride; Rattus norvegicusAbstract
ABSTRACT
Elevated triglyceride levels can be managed through non-pharmacological approaches, including the use of moringa seeds. These seeds are rich in fatty acids that exhibit potential in reducing hyperlipidemia. This research is designed to assess the impact of moringa seed oil on triglyceride concentrations in male Wistar strain white rats (Rattus norvegicus) administered with different doses. Utilizing a Posttest-Only Control Group Design, the experiment was conducted across five groups: K1 (positive control), K2 (negative control), K3 (3 mL moringa seed oil), K4 (6 mL moringa seed oil), and K5 (9 mL moringa seed oil). Measurements were taken after treatment. Statistical analysis revealed a significant difference in triglyceride levels between the negative control group and the groups treated with moringa seed oil (p = 0.018, p < 0.05), indicating the oil's effectiveness in reducing triglyceride levels. Furthermore, Post-Hoc LSD analysis showed a significant difference between K4 and K5, with p = 0.045 (p < 0.050). These findings suggest that moringa seed oil significantly reduces triglyceride levels, particularly at higher doses. This research determided the therapeutic potential of moringa seed oil in managing hyperlipidemia by lowering blood triglyceride levels in male Wistar rats (Rattus norvegicus).
References
Abdulkarim, S. M., Long, K., Lai, O. M., Muhammad, S. K. S., & Ghazali, H. M. (2005). Some physico-chemical properties of Moringa oleifera seed oil extracted using solvent and aqueous enzymatic methods. Food Chemistry, 93(2), 253?263. https://doi.org/10.1016/j.foodchem.2004.09.023
Amalia, A., Sari, I., Nursanty, R., Farmasi, J., Matematika, F., Pengetahuan, I., Universitas, A., Kuala, S., & Biologi, J. (2017). Aktivitas Antibakteri Ekstrak Etil Asetat Daun Sembung (Blumea Balsamifera (L.) Dc.) Terhadap Pertumbuhan Bakteri Methicillin Resistant Staphylococcus Aureus (MRSA). Prosiding Seminar Nasional Biotik, 387?391.
Anudeep, S., & Radha, C. (2018). Carbohydrates of Moringa oleifera seeds. International Journal of Research and Analytical Reviews, 5(4), 103?107. http://ijrar.com/
C. Vauthey, M., G.R. de Freitas, MD; G. van Melle, P., G. Devuyst, M., & J. Bogousslavsky, M. (2000). Better outcome after stroke with higher serum cholesterol levels. 54, 1944?1948.
Cabral, C. E., & Klein, M. R. S. T. (2017). Phytosterols in The Treatment of Hypercholesterolemia and Prevention of Cardiovascular Diseases. In Arquivos Brasileiros de Cardiologia (Vol. 109, Issue 5, pp. 475?482). Arquivos Brasileiros de Cardiologia. https://doi.org/10.5935/abc.20170158
Divya, S., Pandey, V. K., Dixit, R., Rustagi, S., Suthar, T., Atuahene, D., Nagy, V., Ungai, D., Ahmed, A. E. M., Kovs, B., & Shaikh, A. M. (2024). Exploring the Phytochemical, Pharmacological and Nutritional Properties of Moringa oleifera: A Comprehensive Review. In Nutrients (Vol. 16, Issue 19). https://doi.org/10.3390/nu16193423
Gopalakrishnan, L., Doriya, K., & Kumar, D. S. (2016). Moringa oleifera: A review on nutritive importance and its medicinal application. In Food Science and Human Wellness (Vol. 5, Issue 2, pp. 49?56). Elsevier B.V. https://doi.org/10.1016/j.fshw.2016.04.001
Kesehatan Masyarakat, J., Aritzah, N., Andi Palloge, S., Putri Indarwati Abdullah, R., Studi Pendidikan Profesi Dokter Umum Fakultas Kedokteran UMI, P., Ilmu Kesehatan Masyarakat Fakultas Kedokteran UMI, D., & Author, C. (2024). Pengaruh Pemberian Minyak Zaitun Extra Virgin Terhadap Profil Lipid Pasien Hiperkolesterolemia. PREPOTIF: Jurnal Kesehatan Masyarakat, 8(3), 4868?4886.
Leone, A., Spada, A., Battezzati, A., Schiraldi, A., Aristil, J., & Bertoli, S. (2016). Moringa oleifera seeds and oil: Characteristics and uses for human health. In International Journal of Molecular Sciences (Vol. 17, Issue 12). MDPI AG. https://doi.org/10.3390/ijms17122141
M. Guli, M., Priyandini, N., Lambui, O., Ardiputra, Muh. A., & Toemon, A. I. (2024). Uji efektivitas antibakteri ekstrak daun kayu hitam (Diospyros celebica Bakh.) terhadap bakteri Staphylococcus aureus dan Salmonella typhi. Jurnal Kedokteran Universitas Palangka Raya, 12(1). https://doi.org/10.37304/jkupr.v12i1.13189
Mehta, L. K., Balaraman, R., Amin, A. H., Bafna, P. A., & Gulati, O. D. (2003). Effect of fruits of Moringa oleifera on the lipid profile of normal and hypercholesterolaemic rabbits. Journal of Ethnopharmacology, 86(2?3), 191?195. https://doi.org/10.1016/S0378-8741(03)00075-8
Mishra, G., Singh, P., & Kumar, S. (2011). Traditional uses, phytochemistry and pharmacological properties of Moringa oleifera plant: An overview. Der Pharmacia Lettre, 3(2), 141?164. www.scholarsresearchlibrary.com
Mutia, S., & Zairin Thomy, dan. (2018). Pengaruh Pemberian Ekstrak Etanol Daun Andong (Cordyline fruticosa (L.) A. Chev) Terhadap Kadar Kolesterol Total dan Trigliserida Darah Tikus Putih (Rattus norvegicus) Hiperkolesterolemia. In Jurnal Bioleuser (Vol. 2, Issue 2). http://www.jurnal.unsyiah.ac.id/bioleuser/
Olalekan Elekofehinti, O., Gbadura Adanlawo, I., Ayodeji-John Saliu, J., & Adamson Shodehinde, S. (2014). Saponins from Solanum anguivi fruits exhibit hypolipidemic potential in Rattus novergicus. https://www.researchgate.net/publication/252930638
Pareek, A., Pant, M., Gupta, M. M., Kashania, P., Ratan, Y., Jain, V., Pareek, A., & Chuturgoon, A. A. (2023). Moringa oleifera: An Updated Comprehensive Review of Its Pharmacological Activities, Ethnomedicinal, Phytopharmaceutical Formulation, Clinical, Phytochemical, and Toxicological Aspects. In International Journal of Molecular Sciences (Vol. 24, Issue 3). MDPI. https://doi.org/10.3390/ijms24032098
Puspita, I., & Irawan, Y. (2021). Pengaruh Pemberian Ekstrak Etanol Herba Bandotan (Ageratum Conyzoides) Terhadap Penurunan Kadar Kolesterol Total Dan Trigliserida Pada Mencit (Mus Musculus) Hiperlipidemia. In Jurnal Borneo Cendekia (Vol. 5, Issue 1).
Rahman, F., Nadeem, M., Azeem, M. W., & Zahoor, Y. (2014). Comparison of Chemical Characteristics of High Oleic Acid Fraction of Moringa oleifera Oil with Some Vegetable Oils. In J. Anal. Environ. Chem (Vol. 15, Issue 1).
Rajanandh, M. G., Satishkumar, M. N., Elango, K., & Suresh, B. (2012). Moringa oleifera Lam. A herbal medicine for hyperlipidemia: A pre-clinical report. Asian Pacific Journal of Tropical Disease, 2(SUPPL2). https://doi.org/10.1016/S2222-1808(12)60266-7
Riskah, F., Ridhay, A., Abd Rahim, E., Soekarno Hatta Km, J., & Bumi Tadulako Tondo Palu, K. (2019). Produksi Metil Oleat Melalui Reaksi Metanolisis Minyak Biji Kelor (Moringa Oleifera Lam). KOVALEN: Jurnal Riset Kimia, 5(1), 1?8.
Salman, A. N., Prangdimurti, E., & Hunaefi, D. (2023). Peningkatan Potensi Biji Kelor (Moringa oleifera) sebagai Pangan Pencegah Hiperkolesterolemia. Jurnal Ilmu Pertanian Indonesia, 28(4), 525?533. https://doi.org/10.18343/jipi.28.4.525
Siahaan, T. N., Basuki, & Amir Hamzah. (2023). Phytochemical Screening and Chemical Compounds of Moringa Oleifera Leaf Hot Water Extract. International Journal of Ecophysiology, 5(2), 1?7. https://doi.org/10.32734/ijoep.v5i2.13410
Singh, A. (2018). Ethnomedicinal, Pharmacological and Antimicrobial Aspects of Moringa oleifera Lam.: A review. Phytopharmacology, 7(1), 45?50. www.phytopharmajournal.com
Sinulingga, B. O. (2020). Pengaruh Konsumsi Serat dalam Menurunkan Kadar Kolesterol. Jurnal Penelitian Sains, 1, 9?15. https://doi.org/10.26554/jps.v22i1.556
Tridiganita Intan Solikhah, & Gahastanira Permata Solikhah. (2024). Effect of Ethanol Extract from Kersen Leaves (Muntingia calabura L.) on Changes in Blood Factors Total Cholesterol, Triglycerides, LDL and HDL in Hyperlipidemia Mice. Research Journal of Pharmacy and Technology (RJPT), 17(2).
Unuigbe, C., Okeri, H., Erharuyi, O., Oghenero, E., & Obamedo, D. (2015). Phytochemical and antioxidant evaluation of Moringa oleifera (Moringaceae) leaf and seed. Journal of Pharmacy & Bioresources, 11(2), 51. https://doi.org/10.4314/jpb.v11i2.4
Upadhyay, P., Kumar Mishra, S., & Purohit, P. (2015). The user has requested enhancement of the downloaded file. In Int J Res Pharm Sci (Vol. 2015, Issue 2). www.ijrpsonline.com
