Analgesic Effectiveness of Temu Blenyeh (Curcuma Purpurascens Blume) Extract On Male Mice
Keywords:
Ekstrak temu blenyeh, efek analgetik, geliat mencit, efektivitas analgesikAbstract
Pain is a sign of tissue damage in the body. Extracts from the Zingiberaceae family have been proven to be hypoalgesic agents and are superior to non-steroidal anti-inflammatory drugs. The aim of the research was to determine the analgesic effectiveness of the ethanol extract of temu blenyeh (Curcuma purpurascens Blume). The analgesic effectiveness test was carried out using the writhing method (Sigmund) on male white mice (Mus musculus) as test animals. The test animals used were 25 mice grouped into 5 consecutive treatment groups, namely Group 1 (aquadest), Group 2 (antalgin), group 3 (Dose 50 mg/kg BW), group 4 (Dose 100 mg/kg BW) and group 5 (Dose 150 mg/kg BW). The test sample was given orally, after 30 minutes the sample wasthen induced with 1% acetic acid intraperitoneally. Observed and calculated the cumulative number of writhing for 1 hour and calculated the percent writhing protection and percent analgesic effectiveness. The data obtained in the form of the cumulative number of stretches was analyzed by Anova test. The research results showed that the ethanol extract of temu blenyeh provided a percentage of protection respectively (44.5%; 50.14%; 57.64%) and the greatest percentage of analgesic effectiveness at a dose of 150 mg/kg BW of 99.07%. Data analysis showed that ethanol extract with a dose of 50; 100 and 150 mg/kg BW did not have a significant difference to the positive control, which means the sample had analgesic effectiveness.
References
Afriati, R., Revi. Y. & Meustika. (2014). Uji Aktivitas Analgetik Ekstrak Etanol Daun Pepaya (Carica papaya L.) pada Mencit Putih Jantan yang di Induksi Asam Asetat 1%. Jurnal Sains Farmasi Dan Klinis, 1(1). https://doi.org/10. 29208/jsfk.2014.1.1.12
Bajuber, Q., Indiastuti, D. N., & Kusuma, E. (2020). Efek Analgesik Ekstrak Etanol Zingiber cassumunar Roxb . pada Mencit dengan Metode Writhing Test. Jurnal Medik Veteriner, 3(1), 45?50. https://doi.org/10. 20473/jmv.vol3.iss1.2020.45-50.
Depkes RI (2017). Farmakope Herbal Indonesia Edisi II . Jakarta. Kementrian Kesehatan Republik Indonesia.
Dewi,R., & Salim. H. (2018). Uji Efek Analgetik Infusa Jahe (Zingiber officianale R.) Terhadap Hewan Uji Mencit Jantan (Mus Musculus). Media Farmasi Poltekkes Makasar, 15(2) https://doi.org/10.32382/mf.v14i2.585
Fadhilla, G., Adnyana, I. K. & Chaniago, R. (2020). Analgetic Activity Of Ethanol Extract Of Ciplukan Leaves (Physalis Peruviana L.) On Male Swiss Webster Mice By Stretching Method (Sigmund). Jurnal Ilmiah Farmako Bahari, 11(1), 75?88. http://dx. doi.org/10.52434/jfb.v11i1.716
Hanwar, D., Elisafitri, O., & Suhendi, A. (2019). Standardisasi Ekstrak Rimpang Lempuyang Gajah (Zingiber Zerumbet Smith). 9(1), 345?351.
Kharisma et al. (2020). Uji Aktivitas Analgesik Daun Trembesi (Samanea saman (Jacq.) Merr.). Jurnal Wiyata, 7(2), 138?146.
Lahamendu, B., Bodhi, W. & Siampa, J., P. (2019). Uji Efek Analgetik Ekstrak Etanol Rimpang Jahe Putih (Zingiber officinale Rosc.var. Amarum) Pada Tikus Putih Jantan Galur Wistar (Rattus norvegicus). Pharmacon, 8(4), 927. https://doi.org/10.35799/pha.8.2019.29372
Lara, A.D., Elisma & Sani, F. (2021). Uji Aktivitas Analgesik Infusa Daun Jeruju (Acanthus ilicifolius L) Pada Mencit Putih Jantan (Mus musculus) Indonesian Journal of Pharma Science, 3(2), 71?80. https://doi.org/1 0.33482/jmedfarm.v1i01.2
Pramiastuti, O., & Murti, F. K. (2022). Fitokimia dan Aktivitas Antioksidan Ekstrak Temu Blenyeh (Curcuma purpurascens Blumae). Jurnal Ilmiah Kesehatan, 15(1), 12?22. https://doi.org/10.48144/jiks.v15i1.627
Putra, F. A ., Suharti, N., & Arifin, H. (2021). Efek Analgetik Ekstrak Etanol Rimpang Gandasuli (Hedycium Coronarium) Pada Mencit Putih Jantan. Human Care Journal, 6(2), 339. https://doi.org/10.32883/hcj.v6i2.1225
Sani, F., Nazifah, N., & Muhaimin. (2022). Uji Aktivitas Analgetik Ekstrak Etanol Daun Ekor Naga (Rhaphidophora pinnata (L.f) schott) Pada Mencit Putih Jantan. Jurnal Ilmiah Pharmacy, 9(1), 35?48.https://doi.or g/10.52161 /jiphar.v9i1.396
Sumonda, J. B., Mongie, J., Karauwan, F. A., & Lengkey, Y. K. (2021). Uji Efektivitas Ekstrak Etanol Rimpang Lengkuas Putih (Alpinia galanga ( L ) Willd ) Sebagai Analgesik Pada Tikus Putih ( Rattus norvegicus ). Jurnal Biofarmasetikal Tropis, 4(2), 53?59. https://doi.org/ 10.55724/j.biofar.trop. v4i2.360
Thompson, E. B. (1985). Drug Bioscreening. Graceway Publishing Company.
Wijanarko, A., Perawati, S., & Andriani, L. (2020). Standardisasi Simplisia Daun Ciplukan. Jurnal Farmasetis, 9(1), 31?40. http s://doi.org/10.3 2583/farmas etis.v9i1.736
Winda Suwandi, D., Puspita, T., Nuari, D. A., & Hamdani, S. (2021). Aktivitas Analgetika dan Antiinflamasi Ekstrak Etanol dan Fraksi Daun Jambu Mawar (Syzygium jambos L.) SecaraIn Vivo. Jurnal Sains Dan Kesehatan, 3(2), 218?226. https://doi.org/10.25026/jsk.v3i2.279
