Pengaruh Pemberian Jus Daun Katuk, Jus Daun Ubi Jalar, dan Kefir Terhadap Profil Hematologi Mencit Anemia yang Diinduksi Alumunium Sulfat

Authors

  • I Ketut Adnyana Pharmacology-Clinical Pharmacy Research Group, School of Pharmacy, ITB, Indonesia
  • Arief Rosmadi Pharmacology-Clinical Pharmacy Research Group, School of Pharmacy, ITB, Indonesia
  • Joseph Iskendiarso Sigit Pharmacology-Clinical Pharmacy Research Group, School of Pharmacy, ITB, Indonesia
  • Siti Farah Rahmawati Pharmacology-Clinical Pharmacy Research Group, School of Pharmacy, ITB, Indonesia

DOI:

https://doi.org/10.5614/api.v37i2.4042

Abstract

Daun katuk, daun ubi jalar, dan kefir secara empiris digunakan dalam penanganan kondisi anemia. Penelitian ini bertujuan untuk menentukan pengaruh pemberian jus daun katuk, jus daun ubi jalar, serta kefir terhadap profil hematologi mencit anemia. Mencit diinduksi anemia menggunakan larutan alumunium sulfat selama 12 hari berturut-turut kemudian dilanjutkan dengan pemberian sediaan uji selama 14 hari berturut-turut. Profil hematologi mencit diamati pada hari ke-0, 12, 15, 19, 22, dan 26. Mencit yang diinduksi anemia mengalami anemia kronis, di mana 80% kelompok kontrol mengalami kematian setelah hari ke-19, sedangkan mencit dari ketiga sediaan uji tetap hidup tetap hidup sampai hari ke-26. Pada pengukuran rata-rata jumlah hemoglobin, jumlah eritrosit, dan persen hematokrit pada hari ke-19, kelompok mencit yang diberikan jus daun katuk memberikan hasil yang paling baik dibandingkan kelompok yang diberikan jus daun ubi jalar dan kefir. Pemberian jus daun katuk, jus daun ubi jalar, dan kefir dapat memperbaiki profil hematologi mencit anemia lebih baik dibandingkan kelompok kontrol. Ketiga sediaan juga mampu
mempertahankan hidup mencit yang menderita anemia. Jus daun katuk mempu memperbaiki profil hematologi paling baik dibandingkan jus daun ubi jalar dan kefir.

Kata kunci: Daun katuk, daun ubi jalar, kefir, anemia.

Star gooseberry leaves, sweet potato leaves, and kefir empirically used as treatment for anemia. This study aimed to examine the effect of star gooseberry leaves juice, sweet potato leaves juice, and kefir on hematology profiles of anemic mice. Mice was induced by alumunium sulfate solution for 12 consecutive days followed by the testing materials for 14 consecutive days. Hematology profile of mice was observed on day 0, 12, 15, 19, 22, and 26. The induced mice developed chronic anemia. 80% of the control group died after day 19, whereas the testing groups survived until day 26. On day 19, the gooseberry leaves juice group showed the best and significant result on the hemoglobin profile, erythrocytes profile, and hematocrite percentages. Star gooseberry leaves, sweet potato leaves, and kefir improved the hematology profile better than control group and was able to keep the anemic mice alive. Star gooseberry leaves had the best effect on improving the hematology profile of anemic mice.

Keywords: Star gooseberry leaves, sweet potato leaves, kefir, anemia.

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Published

2017-03-13

How to Cite

Adnyana, I. K., Rosmadi, A., Sigit, J. I., & Rahmawati, S. F. (2017). Pengaruh Pemberian Jus Daun Katuk, Jus Daun Ubi Jalar, dan Kefir Terhadap Profil Hematologi Mencit Anemia yang Diinduksi Alumunium Sulfat. Acta Pharmaceutica Indonesia, 37(2), 54-58. https://doi.org/10.5614/api.v37i2.4042

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Section

Research Articles